2011 Fiscal Year Final Research Report
The molecular mechanisms of migration of GnRH neurons and GnRH axon projection to the median eminence.
| Project/Area Number |
21590203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Masato 順天堂大学, 医学部, 准教授 (80347210)
SASAKI Mitsuho 順天堂大学, 医学部, 助教 (20432536)
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| Project Period (FY) |
2009 – 2011
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| Keywords | GnRHニューロン / 軸索ガイダンス分子 / セマフォリン3A / ニューロピリン1 / スリット / ニワトリ胚 / ニューロン移動 / 軸索伸長 |
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| Research Abstract |
Migration assays in coculture explants of GnRH neurons in the embryonic chick dorsal septum region demonstrated that semaphorin 3A-neuropilin 1 signaling act as a chemorepulsive cue for the migration of GnRH neurons in the forebrain. In Slit1 ; Slit2 double mutant mice, GnRH neuron migration toward the caudal region was disturbed and GnRH axon projections to the median eminence were severely reduced. It is possible that the aberrant crossing fibers in the preoptic area led to a defect of GnRH neuron migration and a disruption of GnRH axonal pathfinding as a physical barrier.
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