2011 Fiscal Year Final Research Report
Research of the role of BNP and NOTCH signals for cardiac atrioventricular valve formation
| Project/Area Number |
21590205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
INAI Kei 東京女子医科大学, 医学部, 講師 (80318063)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生学・形態形成学 / 心臓発生 / 房室弁 / NOTCHシグナル |
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| Research Abstract |
Formation of the endocardial cushion mesenchyme in the atrioventricular(AV) canal is the essential morphogenetic step in cardiac valvuloseptal morphogenesis. Numerous studies demonstrated that BMP-2 signaling promotes mesencymal cells differentiation into pre-valvular fibroblasts.
In this study, we showed that BMP-2 induces expression of Notch1 and Notch pathway intermediates in the endocardial cushion mesenchymal cells(ECMC) aggregate culture. We also demonstrated that BMP-2 induces the valvulogenic phenotype including hyarulonan expression and cellular migration and inhibits expression of alternative mesodermal lineage markers in chick ECMC cultures.
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