2011 Fiscal Year Final Research Report
Distribution of Intraepithelial lymphocytes in the murine small intestine : The variability of the morphological property and function
| Project/Area Number |
21590207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOH Tsunetoshi 東北大学, 大学院・医学系研究科, 教授 (90004746)
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Masaki 東北大学, 大学院・医学系研究科, 助教 (50311907)
KASAHARA Shigeru 東北大学, 大学院・医学系研究科, 非常勤講師 (70372290)
MATUTANI Takaji 東北大学, 大学院・医学系研究科, 助教 (70372290)
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| Project Period (FY) |
2009 – 2011
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| Keywords | IEL / 小腸 / マウス / DNA断片化 / 免疫組織化学 / 電子顕微鏡 / Flow Cytometry |
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| Research Abstract |
Different intestinal intraepithelial lymphocytes (IEL)subgroups (presence of granules, etc.)in different villus sites were demonstrated by morphological analysis. Granzyme B (GrB)has been proved to be involved in the induction of DNA fragmentation of epithelial cells due to IEL activation, the results suggest the possibility of a new DNA fragmentation induction mechanism different from that of previously reported perforin (Pfn)/GrB system. We also found that IELs in the front line of the intestinal defense system are highly stimulus-sensitive, thus are disposable, and, when stimulated, finally causing DNA fragmentation in the surrounding villus epithelial cells.
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Research Products
(15 results)
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[Journal Article] The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destruction.2009
Author(s)
shida S, Yamane S, Nakano S, Yanagimoto T, Hanamoto Y, Maeda-Tanimura M, Toyosaki-Maeda T, Ishizaki J, Matsuo Y, Fukui N, Itoh T, Ochi T, Suzuki R.
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Journal Title
Immunology.
Volume: 125
Pages: e315-24
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[Journal Article] T cell receptor repertoire in BALB/c mice varies according to tissue type, sex, age, and hydrocortisone treatment.2009
Author(s)
Kitaura K, Kanayama K, Fujii Y, Shiobara N, Tanaka K, Kurane I, Suzuki S, Itoh T, Suzuki R.
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Journal Title
Experimental Animals.
Volume: 58
Pages: 159-168
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