2011 Fiscal Year Final Research Report
Receptor tyrosine kinase-mediated development and differentiation of interstitial cells in the gastrointestinal tract
| Project/Area Number |
21590213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Fukui |
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Principal Investigator |
IINO Satoshi 福井大学, 医学部, 教授 (40242854)
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| Co-Investigator(Kenkyū-buntansha) |
HORIGUCHI Kazuhide 福井大学, 医学部, 講師 (20377451)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Satomi 福井大学, 医学部, 特命助教 (00595283)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 消化管間質細胞 / カハール介在細胞 / 消化管神経系 / Wミュータントマウス / c-Kit / PDGF受容体α / SK3チャネル / 消化管運動 |
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| Research Abstract |
We observed the expression of receptor tyrosine kinase, c-Kit and PDGFRα, that are specific markers of interstitial cells of Cajal and fibroblast-like cells in the murine gastrointestinal tract. c-Kit expression was observed in gastrointestinal tract from mid embryonic stage. W mutant mice that have c-kit mutations showed cell type specific deficiency of interstitial cells of Cajal. PDGFRαexpression in gastrointestinal tract was observed from early embryonic stage in mesoderm cells and in fibroblast-like cells in late embryonic stage.
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