2011 Fiscal Year Final Research Report
Expression and functional roles of angiopoietins in lymphangiogenesis and development of lymphatic induction system
| Project/Area Number |
21590217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Oita University of Nursing and Health Sciences (2010-2011)
Oita University (2009) |
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Principal Investigator |
SHIMODA Hiroshi 大分県立看護科学大学, 看護学部, 教授 (20274748)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Masahiro 大阪大谷大学, 薬学部, 教授 (50174280)
DAA Tsutomu 大分大学, 医学部, 准教授 (10217218)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リンパ管新生 / アンジオポエチン / リンパ管誘導 / 分子形態学 / リンパ浮腫 |
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| Research Abstract |
A new lymphangiogenesis model with our own produced intermediately-processed(imp) VEGF-C, a specific lymphangiogenic factor, was established. The role of Angiopoietin(Ang)-2, another molecule regulating lymphatic vascular formation, in lymphangiogenesis was further defined using our model. On the basis of these results, we have developed a highly lymphangiogenic system with a mixture of impVEGF-C and Ang-2, and this provides a new therapeutic strategy for lymphedema.
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