2011 Fiscal Year Final Research Report
Analyses of novel genes expressed in the embryonic spinal cord with reference to the sensory axonal guidance
| Project/Area Number |
21590218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAI Nobuyuki 福島県立医科大学, 医学部, 助教 (50301750)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞・組織 / 発生・分化 / 神経科学 / 脳・神経 |
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| Research Abstract |
During early development, the dorsal spinal cord-derived cue chemoattracts dorsal root ganglion(DRG) axons toward the dorsal root entry zone. To identify the molecular nature of this chemoattraction, we examined the function of novel genes expressed in the embryonic dorsal spinal cord. We revealed that a protein encoded by mouse Fukushima 1(mF1) exerted an attractive activity for DRG axons. These results suggest that mF1 may be a candidate for the dorsal spinal cord-derived attractant.
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Research Products
(16 results)
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[Journal Article] Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons2011
Author(s)
Kenta Kobayashi, Tomoyuki Masuda, Masanori Takahashi, Jun-ichi Miyazaki, Masahiro Nakagawa, Motokazu Uchigashima, Masahiko Watanabe, Hiroyuki Yaginuma, Noriko Osumi, Kozo Kaibuchi, Kazuto Kobayashi
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Journal Title
European Journal of Neuroscience
Volume: 33(4)
Pages: 612-621
Peer Reviewed
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