2011 Fiscal Year Final Research Report
A study for the role of bone marrow stromal cells in hematopoietic regulation
| Project/Area Number |
21590223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nihon University |
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Principal Investigator |
AIZAWA Shin 日本大学, 医学部, 教授 (30202443)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞分化・組織形成 / 造血微小環境 / 骨髄ストローマ細胞 |
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| Research Abstract |
The proliferation and differentiation of hematopoietic stem cells are regulated by bone marrow microenvironment. Stromal cells, as distinguished from hematopoietic cells, are an essential compartment of this microenvironment. In this study, the stromal cells are shown to regulate the proliferation and differentiation of hematopoietic cells through the mechanism by producing diffusible hematopoietic regulatory factors. Further, a novel in vitro three-dimensional(3D) hematopoietic culture system is developed, and the importance of stromal cells to regulate hematopoietic cell growth is also clarified.
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[Journal Article] Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment2012
Author(s)
Aisaki K., Tsuboi I., Harada T., Oshima H., Yamashita A., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
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Journal Title
Exp Biol Med
Volume: 237
Pages: 279-286
Peer Reviewed
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[Journal Article] Mast cell development and biostresses : different stromal responses in bone marrow and spleen after treatment of myeloablator, 5-fluorouracil, and inflammatory stressor, lipopolysaccharide2011
Author(s)
Hokari T., Tsuboi I., Harada T., Oshima H., Hirabayashi Y., Kanno J., Inoue T., Aizawa S
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Journal Title
Biol Pharma Bull
Volume: 34
Pages: 1533-1541
Peer Reviewed
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