The role of Sox13 in the signaling pathway that controls epithelial-mesenchymal interaction

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Nippon Medical School
• Principal Investigator: OSADSA Shin-ichi 日本医科大学, 医学部, 助教 (00244484)
• Project Period (FY): 2009 – 2011
• Keywords: 細胞分化 / 組織形成 / 発生・分化 / 毛包形成 / 転写因子 / Sox

Research Abstract

Hair grows through the hair cycle consisting of anagen, catagen and telogen. We investigated the role of Sox13, a member of the Sox family of transcription factors that are involved in cell fate determination and differentiation, using Sox13 mutant mice. We found that Sox13 expression in hair follicle is dynamically changed during hair cycles, indicating that Sox13 is a novel hair cycle maker. Elucidation of the mechanism underlying the Sox13 cyclic expression would be important for understanding the pathogenesis of alopecia.

Research Products

• [Journal Article] Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth (2009)
  • Author(s): K ato M, Hasunuma N, Nakayama R, Takeda J, Itami S, Taira M, Manabe M, Osada S
  • Journal Title: J Dermatol Sci Volume: 53 Pages: 234-236
  • DOI: Doi:10.1016/j.jdermsci.2008.10.002
  • Peer Reviewed
• [Presentation] 毛周期におけるSox13の発現解析 (2011)
  • Author(s): 能登舞、蓮沼直子、眞鍋求、長田真一
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-12-10
• [Presentation] 表皮の極性形成のメカニズム (2011)
  • Author(s): 長田真一、秋本和憲、大野茂男、川名誠司
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-10
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for melanocyte development (2009)
  • Author(s): 長田真一、大森慎也、稲森雅子、川名誠司、平良眞規
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: 京都
  • Year and Date: 2009-12-04
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for neural crest formation (2009)
  • Author(s): Osada, S., Ohmori, S., Inamori, M., Kawana, S. and Taira, M
  • Organizer: 15th Meeting of the European Society for Pigment Cell Research
  • Place of Presentation: ミュンスター(ドイツ)
  • Year and Date: 2009-09-22