2011 Fiscal Year Final Research Report
Functional coupling between Ca^<2+> influx anf Ca^<2+> release during Ca^<2+> oscillatons in fertilized mammalian eggs
| Project/Area Number |
21590229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
SHIRAKAWA Hideki 電気通信大学, 大学院・情報理工学研究科, 准教授 (40241070)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 受精 / カルシウムシグナリング / カルシウム流入 |
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| Research Abstract |
To elucidate the regulatory mechanism for Ca^<2+> influx pathway in fertilized mammalian eggs, we conducted a series of molecular and physiological experiments to interfere the interactions between Ca^<2+> influx channels on the plasma membrane, TRPC and Orai, and proteins on the ER membrane, STIM. The results suggested that, although none of these proteins participate functionally in the maintenance of the Ca^<2+> oscillations by activating Ca^<2+> influx, STIM1 may have an novel role other than as an activator of store-operated Ca^<2+> entry.
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