2011 Fiscal Year Final Research Report
Physiological significance of tight junction cation selectivity for Na-dependent sugar absorption in the small intestine
| Project/Area Number |
21590236
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
SUZUKI Yuichi 静岡県立大学, 食品栄養科学部, 教授 (50091707)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 上皮機能 / 消化吸収 / 能動輸送 / トランスポータ |
|---|
| Research Abstract |
Glucose and many other nutrients absorption in the mammalian small intestine are mediated by Na-dependent active transport mechanism. The present results have suggested that Na required for these processes is rapidly supplied from the blood side to the lumen through the tight junction, and claudin-15 play a major role in this pathway.
|
Research Products
(8 results)
-
[Journal Article] Loss of claudin-15, but not claudin-2, causes Na deficiency and glucose malabsorption in mouse small intestine2011
Author(s)
Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watababe M, Suzuki Y. and Tsukita S.
-
Journal Title
Gastroenterology
Volume: 140(3)
Pages: 913-923
-
-
[Journal Article] Involvement of DNA fragmentation of enterocytes in mucosal injury to a mouse jejunum incubated in Ussing chambers2009
Author(s)
Inagaki-Tachibana, E., Tsukahara, T., Kaji, K., Eguchi, R, Kanazawa, H, Hayashi, H. and Suzuki, Y.
-
Journal Title
Nagoya J Med Sci
Volume: 71
Pages: 11-18
-
-
-
-
-
