2011 Fiscal Year Final Research Report
Mechanism of neural regulation of pacemaker activity in gastric smooth muscle
| Project/Area Number |
21590237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SUZUKI Hikaru 名古屋市立大学, 大学院・医学研究科, 名誉教授 (80037548)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHITANI Hikaru 名古屋市立大学, 大学院・医学研究科, 教授 (10315905)
KITO Yoshihiko 名古屋市立大学, 大学院・医学研究科, 助教 (60381787)
YAMAMOTO Yoshimichi 名古屋市立大学, 看護学部, 教授 (80145755)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 消化管運動 / 消化吸収 |
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| Research Abstract |
In segments of smooth muscle tissue isolated from the corpus region, a known pacemaker region of the stomach, of the guinea-pig stomach, mechanism of the modulation of slow potentials during stimulation of cholinergic excitatory and nitrergic inhibitory nerves was investigated using electrophysiological technique. In response to cholinergic and nitrergic stimulations, the amplitude of slow potentials was increased or unaltered while the frequency was not altered or reduced, respectively, with no significant change in the membrane potential. The results indicated an involvement of ICC-IM in the neural regulation of pacemaker activity, but with different mechanism.
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[Journal Article] Hypoxia differentially modulates both pacemaker and smooth muscle cell activity in the guinea-pig stomach antrum2009
Author(s)
Nakamura, E., Yokoi, T., Fukuta, H., Tanaka, Y., Yamamoto, Y. and Suzuki, H.
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Journal Title
Journal of Smooth MuscleResearch
Volume: 第45巻
Pages: 149-166
Peer Reviewed
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