2011 Fiscal Year Final Research Report
Isolation and functional expression of novel putative carbon dioxide(CO_2) receptors in respiratory epithelium.
| Project/Area Number |
21590238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
UEDA Takashi 名古屋市立大学, 大学院・医学研究科, 准教授 (90244540)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Shoichi 大阪大学, 大学院・医学系研究科, 教授 (20216063)
UGAWA Shinya 名古屋市立大学, 大学院・医学研究科, 教授 (20326135)
ISHIDA Yusuke 大阪大学, 大学院・医学系研究科, 講師 (30381809)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Shoichi 大阪大学, 大学院・医学系研究科, 教授 (20216063)
ISHIDA Yusuke 大阪大学, 大学院・医学系研究科, 講師 (30381809)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 受容体 / 細胞内シグナル伝達 / 化学感覚 |
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| Research Abstract |
Mouse nasal epithelial cells partially exhibited CO_2-induced intracellular calcium mobilization. These cells did not respond to the ligands that activate proton-sensitive cation channels, such as transient receptor potential vanilloid 1(TRPV1), acid-sensing ion channel(ASIC) 1a, ASIC1b, ASIC2a, ASIC2b and ASIC3.Since the nasal epithelial cells responded to NaHCO_3 solution rather than acidic pH solution, a mechanism for detection of HCO_3-may be involved in nasal CO_2 perception.
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[Journal Article] Acid inhibits TRPV4-mediated Ca^2+influx in mouse esophageal epithelial cells2011
Author(s)
Shikano M, Ueda T, Kamiya T, Ishida Y, Yamada T, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kataoka H, Shimada S, Ugawa S, Joh T
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Journal Title
Neurogastroenterol Motil.
Volume: 23(11)
Pages: 1020-8, e497
DOI
Peer Reviewed
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