2011 Fiscal Year Final Research Report
The Regulation and Pathophysiology of Intracellular Water Metabolism by an Intracellular Aquaporin
| Project/Area Number |
21590242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 水チャネル / 多発性嚢胞腎 / 細胞内 / 小胞体 / 血液脳関門 / ノックアウトマウス |
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| Research Abstract |
This study revealed the importance of endoplasmic reticulum(ER) stress reaction induced by the accumulation of unfold proteins in the ER for the development of polycystic kidneys in AQP11 null mice by comprehensive gene and protein expression surveys of the kidney. Other than the kidney, AQP11 plays some roles in the liver, testis, thymus and brain. It is noteworthy that AQP11 is expressed at the endothelium of cerebral capillaries seemingly for the adaptation of osmotic stresses in the brain.
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[Journal Article] The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function2011
Author(s)
Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K.
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Journal Title
J Biol Chem
Volume: 286
Pages: 3342-3350
DOI
Peer Reviewed
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