2011 Fiscal Year Final Research Report
Functional modification of T-type Ca2+channel gene by methylation and its role in tumor cells
| Project/Area Number |
21590247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 電位依存性カルシウムチャネル / 細胞増殖 / 細胞死 / 癌 / 腫瘍 |
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| Research Abstract |
T-type voltage-gated Ca^<2+> channels have unique electrophysiological properties, which have been assumed to be suitable for physiological action such as controlling the proliferation of various tumor cells. A study of T-type voltage-gated Ca^<2+> channels on tumor development was carried on MCF-7(Human breast adenocarcinoma) cells. Cav3.1, an isoform of T-type channels, inhibited cell proliferation and induced apoptosis, while a different isoform, Cav3.2, had no effect. These suggest that the Cav3.1 channel may act as a tumor suppressor.
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