2011 Fiscal Year Final Research Report
Novel role of neuronal Ca^<2+> sensor-1 as a regulator of cardiac function
| Project/Area Number |
21590248
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
NISHITANI Tomoe 独立行政法人国立循環器病研究センター, 分子生理部, 室長 (50393244)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 分子・細胞生理学 / カルシウム / 心臓 |
|---|
| Research Abstract |
Intracellular Ca^<2+> plays key roles in regulating excitation-contraction coupling(EC) and hypertrophy in the heart. In the immature heart, the structure and function of sarcoplasmic reticulum(SR) is immature ; nonetheless, it is considered a primary source of Ca^<2+> for contraction, suggesting the existence of missing factors that promote SR-dependent EC coupling. We showed that neuronal Ca^<2+> sensor-1(NCS-1), a small Ca^<2+> binding protein, which functions in the heart were unknown, is one such regulator that enhances Ca^<2+> signals and contraction in the immature heart. In addition, NCS-1 expression increases in the early stages of hypertrophy in the adult heart and promotes progression of hypertrophy.
|
-
-
[Journal Article] Perilipin 5, a lipid droplet-binding protein, protects the heart from oxidativeburden by sequestering fatty acid from excessive oxidation2012
Author(s)
Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H, Nomura M, Yanase T, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y, Hashimoto T, Sakai F, Hirose F, Osumi T
-
Journal Title
DOI
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] (新聞報道)(1) 2011年7月8日、毎日新聞朝刊。「子供の心拍調節たんぱく質」
-
[Remarks] (2) 2011年7月8日、産経新聞朝刊。「乳幼児の心不全治療に光」
-
[Remarks] (3) 2011年7月、朝日新聞夕刊。「幼い子の心臓を調節たんぱく質発見」
