2011 Fiscal Year Final Research Report
Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism
| Project/Area Number |
21590255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Shinsuke 鳥取大学, 医学部, 准教授 (60194817)
MICHIO Miyoshi 鳥取大学, 医学部, 助教 (20093627)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ストレス |
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| Research Abstract |
We investigated whether inhalation of green odor(a mixture of equal amounts of trans-2-hexenal and cis-3-hexenal) cures and/or prevents the depressive disorders induced in rats. To this end, we used two behavioral models of depression, forced swim test and learned helplessness paradigms. The present results suggest that green odor has not only a therapeutic, but also a preventive effect on depressive-like states in rats.
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[Journal Article] Green odor and depressive-like state in rats : Toward an evidence-based alternative medicine?2011
Author(s)
Watanabe, T., Fujihara, M., Murakami, E., Miyoshi, M., Tanaka, Y., Koba, S. & Tachibana, H.
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Journal Title
Behavioural Brain Research
Volume: 224(2)
Pages: 290-296
Peer Reviewed
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[Journal Article] Protective effects of ginger against aspirin-induced gastric ulcers in rats Yonago Acta medica2011
Author(s)
Wang, Z., Hasegawa, J., Wang, X., Matsuda, A., Tokuda, T., Miura, N. & Watanabe, T.
Volume
54
Pages
11-19
Peer Reviewed
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[Journal Article] "Green odor" inhalation by rats down-regulates stress-induced increases in Fos expression in stress-related forebrain regions2009
Author(s)
Ito, A., Miyoshi, M., Ueki, S., Fukada, M., Komaki, R. and Watanabe, T.
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Journal Title
Neuroscience Research
Volume: 65(2)
Pages: 166-174
Peer Reviewed
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