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2012 Fiscal Year Final Research Report

Neurotransmitters that regulate prostaglandin E2-induced fever in the region surrounding the organum vasculosum of the lamina terminalis

Research Project

  • PDF
Project/Area Number 21590265
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

OSAKA Toshimasa  独立行政法人国立健康・栄養研究所, 基礎栄養研究部, 上級研究員 (30152101)

Project Period (FY) 2009 – 2012
Keywords体温調節 / 視床下部 / プロスタグランジン / ノルアドレナリン / 一酸化窒素 / 低酸素環境 / エネルギー代謝 / エネルギー代謝
Research Abstract

Prostaglandin E_2-induced fever is established by simultaneous activation of heat production and reduction of heat loss. On the other hand, hypoxic stimulation nduces hypothermia that is caused by an increase in heat loss and a decrease in heat production. Both responses are regulated by mechanisms in the region surrounding the organum vasculosum of the lamina terminalis in the hypothalamus. It was elucidated that the hypoxia-induced responses were mediated by noradrenaline released in this region in anesthetized rats. They were then mediated by synthesis and release of nitric oxide via stimulation of α_1-adrenoceptors in the same region. Then, it was proposed that a glutamatergic projection from this region to the lateral preoptic area is critically involved in the responses

  • Research Products

    (9 results)

All 2012 2011 2010 2009

All Journal Article (5 results) Presentation (4 results)

  • [Journal Article] Hypoxia-induced hypothermia mediated by the glutamatergic transmission in the lateral preoptic area2012

    • Author(s)
      Osaka T
    • Journal Title

      Neuroscience

      Volume: 226 Pages: 73-80

    • DOI

      DOI:10.1016/j.neuroscience.2012.09.033

  • [Journal Article] Thermoregulatory responses elicited by microinjection of L-glutamate and its interaction with thermogenic effects of GABA and prostaglandin E_2 in the preoptic area2012

    • Author(s)
      Osaka T
    • Journal Title

      Neuroscience

      Volume: 226 Pages: 156-164

    • DOI

      DOI:10.1016/j.neuroscience.2012.08.048

  • [Journal Article] Hypoxia-induced hypothermia mediated by noradrenaline and nitric oxide in the rostromedial preoptic area2011

    • Author(s)
      Osaka T
    • Journal Title

      Neuroscience

      Volume: 179 Pages: 170-178

    • DOI

      DOI:10.1016/j.neuroscience.2011.01.056

  • [Journal Article] Nitric oxide mediates noradrenaline-induced hypothermic responses and opposes prostaglandin E_2-induced fever in the rostromedial preoptic area2010

    • Author(s)
      Osaka T
    • Journal Title

      Neuroscience

      Volume: 165 Pages: 976-983

    • DOI

      DOI:10.1016/j.neuroscience.2009.10.069

  • [Journal Article] Heat loss responses and blockade of prostaglandin E_2-induced thermogenesis elicited by α_1-adrenergic activation in the rostromedial preoptic area2009

    • Author(s)
      Osaka T
    • Journal Title

      Neuroscience

      Volume: 162 Pages: 1420-1428

    • DOI

      DOI:10.1016/j.neuroscience.2009.05.030

  • [Presentation] 低酸素刺激によって誘起される低体温反応における視床下部視索前野の機構2012

    • Author(s)
      大坂寿雅
    • Organizer
      第40回自律神経生理研究会
    • Place of Presentation
      新宿区
    • Year and Date
      2012-12-01
  • [Presentation] 視索前野へのグルタミン酸とGABA注入に対する体温調節系の反応2011

    • Author(s)
      大坂寿雅
    • Organizer
      第39回自律神経生理研究会
    • Place of Presentation
      新宿区
    • Year and Date
      2011-12-03
  • [Presentation] 終板器官周囲部でのノルアドレナリンの体温低下作用体温調節2009

    • Author(s)
      大坂寿雅
    • Organizer
      温度受容研究会
    • Place of Presentation
      自然科学研究機構岡崎カンファレンスセンター(岡崎市)
    • Year and Date
      2009-09-10
  • [Presentation] Possible interaction between prostaglandin E_2 and GABA in the mechanisms of fever in the region immediately adjacent to the OVLT2009

    • Author(s)
      Osaka T
    • Organizer
      The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation
    • Place of Presentation
      Matsue, Japan
    • Year and Date
      2009-07-25

URL: 

Published: 2014-08-29  

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