2011 Fiscal Year Final Research Report
Analysis of regulatory mechanisms of cell surface expression of Histamine H3 receptor
| Project/Area Number |
21590267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUKEGAWA Jun 東北大学, 大学院・医学系研究科, 准教授 (30187687)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Teruyuki 東北大学, 大学院・医学系研究科, 教授 (90133941)
NAKAHATA Norimichi 東北大学, 大学院・薬学研究科, 教授 (60045804)
MORIYA Takahiro 東北大学, 大学院・薬学研究科, 准教授 (80298207)
KURAMASU Atsuo 山口大学, 大学院・医学系研究科, 准教授 (90302091)
SATO Takeya 東北大学, 大学院・医学系研究科, 助教 (10312696)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達系 / 細胞表面発現 |
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| Research Abstract |
Histamine H3 receptor has drawn much attention in research community as a potential drug target for sleep wake disorder, eating disorder, and learning-memory disorders. Histamine H3 receptor belongs to the G protein-coupled receptor family and the receptor protein should be transported correctly from ER to cell surface after transcription and translation of the receptor gene in order for the receptor to function properly. This research identified various cellular proteins that interact with carboxy-terminus of Histamine H3 receptor and showed that these proteins regulate the transport of the receptor molecule to the cell surface
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