2011 Fiscal Year Final Research Report
Clarifying the regulatory mechanism of insulin signal in septicemia
| Project/Area Number |
21590271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
YOKOO Hiroki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30332894)
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Yuichi 富山大学, 大学院・医学薬学研究部(医学), 教授 (50156361)
YAMAMOTO Seiji 富山大学, 大学院・医学薬学研究部(医学), 助教 (10456361)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 炎症 / 免疫 |
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| Research Abstract |
We analyzed the insulin signal in septicemia, using the brain and lung tissue in septic model mice. Until the certain period, insulin signal was increased by some defensive mechanisms. However, the signal was reduced gradually, and the degree of tissue damage was increased. Meanwhile, treatment the drugs which maintain the signal reduced the tissue damage. It was expected that the damage in septicemia would be reduced, if we use the protective system via insulin signal, which reduce the oxidative and nitrative stress.
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Research Products
(30 results)
