2011 Fiscal Year Final Research Report
The role of histamine H4 receptor in the development of cancer-related fatigue
| Project/Area Number |
21590279
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARUSAWA Shinya 大阪薬科大学, 薬学部, 教授 (90167601)
YAMAMOTO Kouichi 大阪大学, 大学院・医学系研究科, 助教 (40362694)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヒスタミン / ヒスタミンH4受容体 / 腫瘍壊死因子(TNF)-α / がん治療関連倦怠感 / 抗悪性腫瘍薬 / マクロファージ |
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| Research Abstract |
We hypothesized excessive tumor necrosis factor(TNF)-αproduction via histamine H4 receptor(H4R) is concerned in cancer-therapy related fatigue. We found that cisplatin increased TNF-αmRNA expressions in macrophages. Histamine H4R agonists inhibited the cisplatin-induced TNF-αmRNA expression, but treatment with H4R antagonist aggravated the effect. These results suggest that activation of H4R attenuates cisplatin-induced TNF-αmRNA expression and that H4R agonists are expected to be useful for treatment of cancer-therapy related fatigue.
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