2011 Fiscal Year Final Research Report
A crosstalk between sensory neurons and surrounding cells
| Project/Area Number |
21590280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
NAKATA Yoshihiro 広島大学, 大学院・医歯薬学総合研究科, 教授 (40133152)
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| Research Collaborator |
MORIOKA Norimitsu 広島大学, 大学院・医歯薬学総合研究科, 講師 (20346505)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 知覚神経 / 神経ペプチド / 後根神経節細胞 / サブスタンスP / クロストーク |
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| Research Abstract |
To examine mechanisms underlying substance P(SP) release from primary sensory neurons in response to activation of the nonselective cation channel transient receptor potential ankyrin 1(TRPA1), SP release from cultured rat dorsal root ganglion(DRG) neurons was measured, using radioimmunoassay, by stimulating TRPA1 with allyl isothiocyanate(AITC). The data suggest that activation of TRPA1 evokes SP release from the primary sensory neurons through phosphorylation of p38 MAP kinase, subsequent nociceptive behaviors and inflammatory responses. Furthermore, the data also indicate that blocking the effects in periphery tissue of TRPA1 activation leads to significant antinociception.
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