2011 Fiscal Year Final Research Report
The elucidation of the mechanisms underlying anticancer drug-induced peripheral neuropathy and its prophylaxis.
Project/Area Number |
21590285
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Kyushu University |
Principal Investigator |
OISHI Ryozo 九州大学, 大学病院, 教授 (90112325)
|
Co-Investigator(Renkei-kenkyūsha) |
EGASHIRA Nobuaki 九州大学, 大学病院, 准教授 (80352269)
|
Project Period (FY) |
2009 – 2011
|
Keywords | オキサリプラチン / パクリタキセル / 末梢神経障害 / 機械的アロディニア / 低温 |
Research Abstract |
The present study elucidated that the L type Ca2+ channels/NFAT/TRPM8 pathway plays a key role on oxaliplatin-induced cold hyperalgesia in rats, and Ca2+ channel blockers have prophylactic potential against that acute neuropathy caused by oxaliplatin. It was also found that the up-regulation of spinal NMDA receptor NR2B subunit involves in oxaliplatin-induced mechanical allodynia. Moreover, ifenfrodil and neurotropin could suppress the mechanical allodynia induced by oxaliplatin in rats.
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Research Products
(28 results)