2011 Fiscal Year Final Research Report
Drug development using accelerated aging model
Project/Area Number |
21590289
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Jichi Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Hiroyoshi 自治医科大学, 医学部, 助教 (80508755)
|
Project Period (FY) |
2009 – 2011
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Keywords | バゾプレッシン / リポフスチン / 副腎皮質 / ノックアウトマウス |
Research Abstract |
Vasopressin is known to promote cellular growth and protein synthesis in adrenocortical and other cell types. We examined the role of V1a receptor in steroid secretion and cellular aging in adrenal cortex. In adrenocortical cell line, vasopressin promoted glucocorticoid secretion when applied alone or together with adrenocortical hormone. This study also found that V1a knockout mouse is an excellent model for studying aging in adrenocortical cells.
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Research Products
(2 results)
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[Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human2012
Author(s)
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Korner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, and Froguel P.
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Journal Title
Nature
Volume: 483
Pages: 350-354