2011 Fiscal Year Final Research Report
Identification of D-serine-related gene and elucidation of etiology of schizophrenia using genetically modified animals
| Project/Area Number |
21590292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 中枢 / 末梢神経 |
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| Research Abstract |
We have investigated the identification of schizophrenia-related genes and the elucidation of genetically modified animals as schizophrenia-model animals using genetically modified animals. Using DNA microarrays, a variety of genes was increased and decreased. A stimulant exposure resulted in the increase of abnormal behaviors in the genetically modified animals compared to the wild mice. These data indicated that the genetically modified animals could be the model animals of schizophrenia.
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Research Products
(3 results)
