2011 Fiscal Year Final Research Report
The role of intracellular calcium and sodium-calcium exchanger in the automaticity of pulmonary vein myocardium.
| Project/Area Number |
21590293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAMEKATA Eyuki 東邦大学, 薬学部, 講師 (30510309)
TAKAHARA Akira 東邦大学, 薬学部, 教授 (80377481)
KAWANISHI Toru 国立医薬品食品衛生研究所, 副所長 (40124383)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肺静脈心筋 / ナトリウムカルシウム交換機構 / 自動能 / 細胞内カルシウム |
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| Research Abstract |
We established glass microelectrode techniques to record the electrical activity of the pulmonary vein myocardium. We also established experimental protocols to constantly isolate pulmonary vein cardiomyocytes and load them with calcium sensitive fluorescent probes, and succeeded in high speed confocal imaging analysis of the intracellular calcium oscillation which precede their electrical activity. Pharmacological analyses led us to the understanding that increased intracellular calcium activates the sodium-calcium exchanger generates a depolarizing inward membrane current, which triggers electrical activity.
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