2011 Fiscal Year Final Research Report
Investigation of the mechanisms involving PTFE graft occlusion and searching its pharmacotherapeutics with chymase inhibitor
| Project/Area Number |
21590295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
JIN Denan 大阪医科大学, 医学部, 講師 (90319533)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 人工血管 / PTFE / グラシル / 狭窄 / アンジオテンシンII / キマーゼ |
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| Research Abstract |
The inside neointima formation of polytetrafluoroethylene(PTFE) grafts may be associated with the migration of outside fibroblasts to the luminal surfaces. In this study we have demonstrated that the migration of outside fibroblasts into inside of the PTFE grafts is indeed participated in the neointima formation by performing a comparative investigation with use of two different types of prosthetic vessels, the porous PTFE graft and the impermeable Grasil graft, respectively.
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