2011 Fiscal Year Final Research Report
PPARγplays an important role in improvement of cognitive decline in Alzheimer's disease model animals complicated by lifestyle deseases.
| Project/Area Number |
21590298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Kenichi 福岡大学, 薬学部, 准教授 (00320309)
TAKASAKI Kotaro 福岡大学, 薬学部, 助教 (70461506)
KATSURABAYASHI Shutaro 福岡大学, 薬学部, 助教 (50435145)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳循環障害 / アルツハイマー病 / PPARγ |
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| Research Abstract |
We made Alzheimer's disease model animals to complicate cerebrovascular disorders, and we proved that defects of memory such as the maze learning disability aggravated. It was supposed that the temporal increase of inflammatory cytokines including TNFα and HMGB1 and apoptosis of neurons in the hippocampus CA1 leaded with the onset of dementia by the cerebrovascular disorders. Furthermore, We were able to improve a spatial memory disorder by activating PPARγwith anti-inflammatory effect and anti-apoptosis effect. It was proved that drugs with PPARγ agonist effect could become the dementia therapeutic drug than this study.
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[Journal Article] Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia2010
Author(s)
Haraguchi T, Iwasaki K, Takasaki K, Uchida K, Naito T, Nogami A, Kubota K, Shindo T, Uchida N, Katsurabayashi S, Mishima K, Nishimura R, Fujiwara M.
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Journal Title
Brain Res
Volume: 24
Pages: 125-32
Peer Reviewed
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