2011 Fiscal Year Final Research Report
Systemic siRNA delivery to prevent interferon-response in animals
| Project/Area Number |
21590305
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
TAKEI Yoshifumi 名古屋大学, 大学院・医学系研究科, 准教授 (70362233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KADOMATSU Kenji 名古屋大学, 大学院・医学系研究科, 教授 (80204519)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | RNA干渉 / siRNA / インターフェロン応答 / 薬物送達 / 自然免疫 |
|---|
| Research Abstract |
RNA interference is an endogenous gene-silencing method that involves double-stranded short RNA(siRNA)-mediated sequence-specific mRNA degradation. Here, we showed intravenously administered siRNA/atelocollagen complex did not induce immunostimulatory adverse effects(interferon-response) in mice. We also found the complex did not entered into peripheral blood mononuclear cells as a reason of the immunostimulatory-null effect of the complex. Atelocollagen is an excellent and promising delivery vehicle, and it has the useful advantage of evading detection by the" radar" of innate immunity.
|
Research Products
(30 results)
-
-
-
-
-
-
[Journal Article] The premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1(LRP1)2011
Author(s)
Sakamoto K, Bu G, Chen S, Takei Y, Hibi K, Kodera Y, MaCormick LM, Nakao A, Noda M, Muramatsu T, Kadomatsu K.
-
Journal Title
J Biol Chem
Volume: 286
Pages: 8405-8413
Peer Reviewed
-
-
[Journal Article] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients2011
Author(s)
Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S.
-
Journal Title
Nephrol Dial Transplant
Volume: 26
Pages: 2322-2332
Peer Reviewed
-
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cellnon-Hodgkin's lymphoma2010
Author(s)
Mihara K, Yanagihara K, Takigahira M, Kitanaka A, Imai C, Bhattacharyya J, Kubo T, Takei Y, Yasunaga S, Takihara Y, Kimura A
-
Journal Title
Br J Haematol
Volume: 151
Pages: 37-46
Peer Reviewed
-
[Journal Article] EWS/Fli-1 chimeric fusion gene up-regulates vascular endothelial growth factor-A2010
Author(s)
Nagano A, Ohno T, Shimizu K, Hara A, Yamamoto T, Kawai G, Saitou M, Takigami I, Matsuhashi A, Yamada K, Takei Y.
-
Journal Title
Int J Cancer
Volume: 126
Pages: 2790-2798
Peer Reviewed
-
-
-
[Journal Article] TGF-SS induces VEGF-C expression leading to lymph angiogenesis in rat unilateral ureteral obstruction
Author(s)
Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y.
-
Journal Title
Peer Reviewed
-
-
[Presentation] Lymphangiogenesis develops during peritoneal fibrosis in peritoneal dialysis patients and rat peritonitis model2011
Author(s)
Kinashi H, Ito Y, Mizuno M, Suzuki Y, Nagura F, Sato W, Tsuboi N, Maruyama S, Imai E, Takei Y, Matsuo S.
Organizer
Renal Week 2011
Place of Presentation
Renal Week 2011
Year and Date
2011-10-08
-
-
-
-
[Presentation] Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. American Society of Nephrology2010
Author(s)
Sawai A, Ito Y, Mizuno, M, Suzuki Y, Toda S, Ito I, Sato W, Tsuboi N, Maruyama S, Imai E, Takei Y, Yuzawa, Y, Matsuo S.
Organizer
Renal Week 2010
Place of Presentation
Colorado Convention Center, Denver, CO, USA
Year and Date
2010-11-16
-
[Presentation] Lymphangiogenesisdevelops during tubulo-interstitialfibrosis via the TGFb-VEGF-C pathwayin rat unilateral ureteral obstruction. American Society of Nephrology2010
Author(s)
Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Sato W, Maruyama S, Imai E, Takei Y, Matsuo S.
Organizer
Renal Week 2010
Place of Presentation
Colorado Convention Center, Denver, CO, USA
Year and Date
2010-11-16
-
-
-
[Presentation] Lymph angiogenesis develop during tubulointer stitial fibrosis in ratunilateral ureteral obstruction viaTGF-VEGF-C pathway2010
Author(s)
Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Sato W, Maruyama S, Takei Y, Imai E, Yuzawa Y, Matsuo S.
Organizer
Emerging Culprits in Pathogenesis and Advances in Therapy
Place of Presentation
Kyoto
Year and Date
2010-04-15
-
-
-
-
-
-
-
