2011 Fiscal Year Final Research Report
The role of sphingosine kinases on the formation of neural network in dentate granule cells of hippocampus
| Project/Area Number |
21590309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
OKADA Taro 神戸大学, 大学院・医学研究科, 准教授 (80304088)
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| Project Period (FY) |
2009 – 2011
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| Keywords | スフィンゴシンキナーゼ / スフィンゴ脂質 |
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| Research Abstract |
It was shown that the long-term potentiation(LTP) which is know to be involved in the memory and learning is not observed in sphingosine kinase 1(SPHK1)-knockout mice. As a consequence the spatial learning ability of the knock out mice was impaired. We also showed that SPHK1 knock down by siRNA diminished the synapse formation in primary hippocampal cells. These results are very important in the sense that the function of hippocampus might be regulated by the medicines which act on the SPHK1-S1P axis. Since over-activation of hippocampal neuron is considered to be involved in the onset of some kind of epilepsy, our finding may provide new treatment strategy of the epilepsy.
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