2011 Fiscal Year Final Research Report
Enzymological analysis of N-acylethanolamines as lipid mediators
| Project/Area Number |
21590310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
UEDA Natsuo 香川大学, 医学部, 教授 (20193807)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBOI Kazuhito 香川大学, 医学部, 助教 (80346642)
UYAMA Toru 香川大学, 医学部, 助教 (30457337)
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| Project Period (FY) |
2009 – 2011
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| Keywords | N-アシルエタノールアミン / アナンダミド / エンドカンナビノイド / N-アシルトランスフェラーゼ / リソソーム / 酵素 / 脂質メディエーター / リン脂質 |
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| Research Abstract |
In the present studies we analyzed enzymes involved in the biosynthesis and degradation of N-acylethanolamines(NAEs), which function as lipid mediators in animal tissues. We found that five proteins belonging to the HRASLS tumor suppressor family have acyltransferase activities, which generate N-acyl-phosphatidylethanolamine(NAPE), a precursor of NAE, and that NAE can be formed not only from NAPE but also from N-acyl-plasmenylethanolamine in brain.
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[Journal Article] Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen througN-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and-independent pathways2011
Author(s)
Tsuboi K, Okamoto Y, Ikematsu N, Inoue M, Shimizu Y, Uyama T, Wang J, Deutsch DG, Burns MP, Ulloa NM, Tokumura A, Ueda N
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Journal Title
Biochim Biophys Acta-Mol Cell Biol Lipids
Volume: 1811
Pages: 565-577
Peer Reviewed
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[Journal Article] Studies on the anorectic effect of N-acylphosphatidyl-ethanolamine and phosphatidylethanolamine in mice2011
Author(s)
Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS
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Journal Title
Biochim Biophys Acta-Mol Cell Biol Lipids
Volume: 1811
Pages: 508-512
Peer Reviewed
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[Journal Article] Protective role of palmitoylethanolamide in contact allergic dermatitis2011
Author(s)
Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tilting T, Bisogno T, De Filippis D, D' Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V
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Journal Title
Allergy
Volume: 65
Pages: 698-711
Peer Reviewed
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