2011 Fiscal Year Final Research Report
Identification of adaptor molecules involved in intracellular transport of cadherins
| Project/Area Number |
21590313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
OZAWA Masayuki 鹿児島大学, 医歯学総合研究科, 教授 (90136854)
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| Project Period (FY) |
2009 – 2011
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| Keywords | カドヘリン / β-カテニン / α-カテニン / 細胞内輸送 |
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| Research Abstract |
E-cadherin is a member of the cadherin family cell-cell adhesion molecules. After synthesis in rough endoplasmic reticulum, E-cadherin is transported to the baso-lateral membrane of epithelial cells, and forms cell adhesion complex called adherens junction. Cadherins forms complexes with α-catenin through the interaction with β-catenin. Uncoupling of β-catenin-binding results in failure of cadherin transport to the cell surface. Chimeric molecules of E-cadherin with α-catenin, however, are transported to the surface. Thus complex formation of cadherins with α-catenin is critical for the transport.
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[Journal Article] Numb controls E-cadherin endocytosis through p120 catenin with aPKC2011
Author(s)
Sato K, Watanabe T, Wang S, Kakeno M, Matsuzawa K, Matsui T, Yokoi K, Murase K, Sugiyama I, Ozawa M, Kaibuchi K
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Journal Title
Mol. Biol. Cell.
Volume: 22
Pages: 3103-3119
URL
Peer Reviewed
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