2011 Fiscal Year Final Research Report
Molecular pathogenesis of the mucosal lesion due to the dysfunction of NHE3-CFTR transportsome
| Project/Area Number |
21590332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Chubu University (2010-2011)
Nagoya University (2009) |
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Principal Investigator |
KONDO Takaharu 中部大学, 生命健康科学部, 教授 (20135388)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGURO Hiroshi 名古屋大学, 総合保健体育科学センター, 教授 (90303651)
YAMAMOTO Akiko 名古屋大学, 総合保健体育科学センター, 准教授 (60402385)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CFTR / NHE3 / HCO_3^-分泌 / SLC26A6 / 膵導管細胞 / 嚢胞性線維症 / 粘膜上皮 / コンピュータシミュレーション |
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| Research Abstract |
For the defense mechanisms of gastrointestinal and respiratory mucosa to work properly, pH of the luminal fluid must be kept neutral～ alkaline. The present study demonstrated that the cell membrane transportsome containing CFTR and NHE3 plays a key role in transmucosal HCO_3^-secretion. A mathematical model of HCO_3^-secretion was constructed using MATLAB/Simulink. The kinetic model of each ion channel/transporter/pump was mounted in the basolateral and apical membranes of the model cell.
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[Journal Article] Structure and function of the pancreas in the polycystic kidney rat2012
Author(s)
Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H
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Journal Title
Pancreas
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis2010
Author(s)
Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H
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Journal Title
Gastroenterology
Volume: 138
Pages: 1988-96
DOI
Peer Reviewed
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