2011 Fiscal Year Final Research Report
Research on early diagnosis of abnormal carbohydrate metabolism by antibody specific for AGEs
| Project/Area Number |
21590340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Japan Women's University |
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Principal Investigator |
NAGAI Ryoji 日本女子大学, 家政学部, 講師 (20315295)
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| Project Period (FY) |
2009 – 2011
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| Keywords | AGEs / メイラード反応 / 糖化 / CML / コラーゲン / 老化 |
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| Research Abstract |
Pentosidine, one of advanced glycation end-products(AGEs), is measured by HPLC in the serum, and increased by heating in a temperature-and time-dependent manner. The increase in pentosidine formation is significantly inhibited by acidic conditions. This indicates that the level of serum pentosidine will be measured more accurately by ELISA if hydrochloric acid is added during the heating process. Furthermore, N^ω-carboxymethylarginine(CMA), acid labile AGE structure, is preferentially generated in glycated collagen. We elucidated the hot-spot of CMA formation in glycated collagen.
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Research Products
(37 results)
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[Journal Article] Natural Compounds Containing a Catechol Group Enhance the Formation of N^ε-(carboxymymethyl) lysine of the Maillard Reaction2011
Author(s)
Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R.
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Journal Title
Free Radic. Biol. Med
Volume: 50(7)
Pages: 883-891
Peer Reviewed
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[Journal Article] Involvement of membrane type-1-matrix metalloproteinase(MT1-MMP) in RAGE activation signaling pathways2011
Author(s)
Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shimoi M, Maruyama Y, Takeishi Y.
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Journal Title
J. Cell. Physiol
Volume: 226(6)
Pages: 1554-1563
Peer Reviewed
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[Journal Article] Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity : the role of macrophage scavenger receptor class A type I and II2010
Author(s)
Ilchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M
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Journal Title
J Allergy Clin Immunol
Volume: 125(1)
Pages: 175-183
Peer Reviewed
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[Journal Article] Angptl 4 Deficiency Improves Lipid Metabolism, Suppresses Foam Cell Formation and Protects Against Atherosclerosis2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Suda T, Oike Y, Araki E
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 379(4)
Pages: 806-811
Peer Reviewed
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