2011 Fiscal Year Final Research Report
Identification of Runx transcriptional factors target genes in regulatory T cell.
| Project/Area Number |
21590348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
NAOE Yoshinori 独立行政法人国立長寿医療研究センター, 研究所老化機構研究部免疫研究室, 室長 (50392048)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫学 / マイクロアレイ |
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| Research Abstract |
The aims of this research are to understand that the function of Runx transcriptional factors and the identification of target genes of Runx transcriptional factors during regulatory T cell(Treg) development. Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyperproduction of IgE. As Cbfβ-deleted Treg cells exhibited impaired suppressive function in vitro and in vivo, Runx transcriptional factors have crucial roles in Treg. We have exhibited that Runx complex regulated Foxp3, IL-4 and IL-10 expression and have identified the expression of several genes were directly regulated Runx transcriptional factors in Treg.
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Research Products
(15 results)
