2011 Fiscal Year Final Research Report
Functional analysis of a novel signal molecule CDCP1 which regulates anchorage-independent growth in cancer cells
| Project/Area Number |
21590350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
UEKITA Takamasa 独立行政法人国立がん研究センター, 研究所, 主任研究員 (50373402)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CDCP1 / 足場非依存性 / 細胞運動能 / 浸潤 / MMP |
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| Research Abstract |
In this study, we found the three functions of CDCP1 in cancer cells. First, CUB2 and CUB3 in the extracellular domain of CDCP1 and the region including Tyrosine734 in the intracellular domain of CDCP1 might contribute to regulate anchorage-independent growth in cancer cell. Second, CDCP1 regulates cancer invasion through regulation of MMP-9 secretion and membranous transportation of MT1-MMP to invadopodia. Finally, induction of CDCP1 expression by Ras along with tyrosine phosphorylation of CDCP1 by Src family kinases is required for Ras-mediated oncogenic phenotypes, such as anchorage-independent growth, invasion and metastasis.
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