2012 Fiscal Year Final Research Report
Nuclear architecture and chromatin
| Project/Area Number |
21590354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | 独立行政法人国立成育医療研究センター (2012)
National Center for Geriatrics and Gerontology (2009-2011) |
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Principal Investigator |
FUKUI Yuko 独立行政法人国立成育医療研究センター, 分子内分泌研究部, 研究員 (50342639)
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| Project Period (FY) |
2009 – 2012
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| Keywords | クロマチン / ゲノム / 性差 / 遺伝子発現制御 |
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| Research Abstract |
Focusing on member of polycomb group, Cbx2, we are investigating the relationship between nuclear architecture and gene regulation. In this project, we approved novel Cbx2 functions on growing long bone in mice. Cbx2 KO tibia had low bone mineral densities, and transcription profile in osteoblasts and adipocytes were clearly altered in KO bone marrow, with 60-100% penetrance. In ST2 cells (mouse bone marrow derived stroma cells), Cbx2 and H3k27me3 histone modification were tethering at the same target loci. These results strongly suggested the direct regulation of tissue specific genes by Cbx2.
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[Journal Article] Cbx2, a polycomb group gene, is required for sry gene expression in mice.2012
Author(s)
Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K.
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Journal Title
Endocrinology
Volume: 153
Pages: 913-924
DOI
Peer Reviewed
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[Journal Article] A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse.2011
Author(s)
Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi M.
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Journal Title
PLoS One
Volume: 6:e25158
DOI
Peer Reviewed
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[Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads.2010
Author(s)
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi KI.
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Journal Title
Endocrinology
Volume: 151
Pages: 5893-5904
DOI
Peer Reviewed
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