2011 Fiscal Year Final Research Report
Regulation of lipid metabolism through nucleotide levels in liver by utilizing AMPD2 KO mice
| Project/Area Number |
21590355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MORISAKI Hiroko 独立行政法人国立循環器病研究センター, 分子生物学部, 室長 (40311451)
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| Co-Investigator(Kenkyū-buntansha) |
MORISAKI Takayuki 独立行政法人国立循環器病研究センター, 分子生物学部, 部長 (30174410)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 代謝異常学 / アデニンヌクレオチド / 肝臓 / AMP / AMPキナーゼ / 脂質代謝 / AMPD |
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| Research Abstract |
Nucleotide metabolism has an important role for lipid metabolism through AMP-activated protein kinase(AMPK) in addition to several known functions. In this study, it was found that the systemic adipose deposition was changed by AMPD2 deficiency. This change was shown to be correlated to changes in the levels of hepatic adenine nucleotide and the phosphorylated condition of AMP. Therefore, the relationship between AMPR2 function and lipid metabolism was newly identified.
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