2011 Fiscal Year Final Research Report
Molecular basis of epigenetics on the mechanisms of sex determination and its failure
| Project/Area Number |
21590357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Kobe University |
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Principal Investigator |
HOSHI Nobuhiko 神戸大学, 大学院・農学研究科, 教授 (10209223)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAWARA Teruo 小樽商科大学, 保管管理センター, 教授 (40250451)
SAKURAGI Noriaki 北海道大学, 医学研究科, 教授 (70153963)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エピジェネティクス / 遺伝子発現制御 / Y染色体 / 性分化 |
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| Research Abstract |
Testis development in mammals begins with the activation of Y-linked Sry gene, which triggers a cascade of events that lead to male pathway. To clarify the regulation mechanism of testis differentiation, we investigated the epigenetic change of the gonadal development of a unique mouse carrying Y^<pos> that showed sex reversal with true hermaphrodites, and clinical case with disorder of sex differentiation(DSD) patient. We showed that the profiles of methylation and acetylation of SRY gene and revealed some of causation of diversity of DSD.
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[Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) exposure decrease : in the spermatozoa stage or at fertilization?2010
Author(s)
Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, TanidaT, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N
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Journal Title
Reprod Toxicol
Volume: 29
Pages: 68-73
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[Journal Article] Global gene profiling and comprehensive bioinformatics analysis of a 46, XY female with pericentric inversion of the Y chromosome2010
Author(s)
Mitsuhashi T, Warita K, Tabuchi Y, Takasaki I, Kondo T, Sugawara T, Hayashi F, Wang ZY, Matsumoto Y, Miki T, Takeuchi Y, Ebina Y, Yamada H, Sakuragi N, Yokoyama T, Nanmori T, Kitagawa H, Kant JA, Hoshi N
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Journal Title
Congenit Anom
Volume: 50
Pages: 40-51
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[Journal Article] Epigenetic abnormality of SRY gene in the adult XY female with pericentric inversion of the Y chromosome2010
Author(s)
Mitsuhashi T, Warita K, Sugawara T, Tabuchi Y, Takasaki I, Kondo T, Hayashi F, Wang ZY, Matsumoto Y, Miki T, Takeuchi Y, Ebina Y, Yamada H, Sakuragi N, Yokoyama T, Nanmori T, Kitagawa H, Kant JA, Hoshi N
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Journal Title
Congenit Anom
Volume: 50
Pages: 85-94
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[Journal Article] Direct effects of diethylstil-bestrol on the gene expression of the cholesterol sidechain cleavage enzyme(P450scc) in testicular Leydig cells2010
Author(s)
Warita K, Mitsuhashi T, Sugawara T, Tabuchi Y, Tanida T, Wang, Z-Y, Matsumoto Y, Yokoyama T, Kitagawa H, Miki T, Takeuchi Y, Hoshi N
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Journal Title
Life Sci
Volume: 87
Pages: 281-285
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[Journal Article] Fetal and neonatal exposure to three typical environmental chemicals with different mechanisms of actions : Mixed exposure to phenol, phthalate, and dioxin causes the effect of sole exposure on mouse midbrain dopaminergic nuclei to disappear2009
Author(s)
Tanida T, Warita K, Ishihara K, Fukui S, Mitsuhashi T, Qi W-M, Inamoto T, Yokoyama T, Kitagawa H, Hoshi N
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Journal Title
Toxicol Lett
Volume: 189
Pages: 40-47
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[Presentation] 遺伝子改変性転換マウス(Ypos)の半陰陽個体生殖腺における発生形態学的研究2010
Author(s)
横山俊史, 宮本良介, 土居弘明, 田阪健, 橋本佳樹, 藤井裕香, 石川恭子, 須谷真巳, 長原大知, 三觜友子, 北川浩, 星信彦
Organizer
第150回日本獣医学会学術集会講演要旨集
Year and Date
20100000
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