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2011 Fiscal Year Final Research Report

Molecular analysis of the CNTN4 knockout mice

Research Project

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Project/Area Number 21590359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionKyushu University

Principal Investigator

IWAKI Akiko  九州大学, 生体防御医学研究所, 講師 (30253454)

Project Period (FY) 2009 – 2011
Keywords遺伝子改変マウス / 自閉症 / 細胞接着因子 / ゲノム
Research Abstract

Contactin 4(Cntn4) is a member of the immunoglobulin super family of axon associated adhesion molecule. Recently, copy number variations of CNTN4 have been detected in several studies on autism spectrum disorders. To explore the dosage effect of Cntn4, we generated mice with targeted disruption of Cntn4. The knockout(KO) mice were viable and fertile and developed normally. Microarray analyses of the prefrontal cortex and olfactory bulb of KO mice revealed several hundred genes with altered expression levels in comparison with the wild type mice.

  • Research Products

    (12 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (5 results)

  • [Journal Article] An autopsy case of adult-onset hereditary spastic paraplegia type 2 with a novel mutation in exon 7 of the proteolipid protein 1 gene2011

    • Author(s)
      Suzuki SO, Iwaki T, Arakawa K, Furuya H, Fujii N, Iwaki A
    • Journal Title

      Acta Neuropathol

      Volume: 122 Pages: 775-781

    • Peer Reviewed
  • [Journal Article] An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions2011

    • Author(s)
      Matsuoka T, Fujii N, Kondo A, Iwaki A, Hokonohara T, Honda H, Sasaki K, Suzuki SO, Iwaki T
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 71-6

    • Peer Reviewed
  • [Journal Article] Partial SPAST and DPY30 deletions in a Japanese spastic paraplegia type 4 family2011

    • Author(s)
      Miura S, Shibata H, Kida H, Noda K, Toyama T, Iwasaki N, Iwaki A, Ayabe M, Aizawa H, Taniwaki T, Fukumaki Y
    • Journal Title

      Neurogenetics

      Volume: 12 Pages: 25-31

    • Peer Reviewed
  • [Journal Article] FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion2010

    • Author(s)
      Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 252-4

    • Peer Reviewed
  • [Journal Article] Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation2010

    • Author(s)
      Tateishi T, Hokonohara T, Yamasaki R, Miura S, Kikuchi H, Iwaki A, Tashiro H, Furuya H, Nagara Y, Ohyagi Y, Nukina N, Iwaki T, Fukumaki Y, Kira JI
    • Journal Title

      Acta Neuropathol

      Volume: 119 Pages: 355-364

    • Peer Reviewed
  • [Journal Article] Comprehensive behavioural study of GluR4 knockout mice : implication in cognitive function2010

    • Author(s)
      Sagata N, Iwaki A, Aramaki T, Takao K, Kura S, Tsuzuki T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Miyakawa T, Fukumaki Y
    • Journal Title

      Genes Brain Behav

      Volume: 9 Pages: 899-909

    • Peer Reviewed
  • [Journal Article] Clinical and genetic characterization of a 2-year-old boy with complete PLP1 deletion

    • Author(s)
      Torisu H, Iwaki A, Takeshita K, Hiwatashi A, Sanefuji M, Fukumaki Y, Hara T
    • Journal Title

      Brain Dev

      Volume: in press

    • Peer Reviewed
  • [Presentation] Molecular mechanisms of behavioral abnormalities of knockout mice of Grm3.2011

    • Author(s)
      Fujioka R, Nii T, Iwaki A, Kitaichi, K, Ito I, Shibata A, Nomura M, Hattori S, Takao K, Miyakawa T and Fukumaki Y.
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2011-12-14
  • [Presentation] Generation and behavioral analysis of GluR4 knockout mice2011

    • Author(s)
      Iwaki A, Sagata N, Aramaki T, Takao K, Miyakawa T, Kawakami R, Ito I, Kitamura T, Sugiyama H, Kura S, Tsuzuki T, Fukumaki Y
    • Organizer
      The 56th Annual Meeting of Japan Society of Human Genetics
    • Year and Date
      2011-11-09
  • [Presentation] Comprehensive behavioral analysis of mGluR3 knockout mice2010

    • Author(s)
      Nii T, Fujioka R, Iwaki A, Hattori S, Takao K, Shibata A, Nomura M, Miyakawa T and Fukumaki Y.
    • Organizer
      The 33 rd Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2010-12-08
  • [Presentation] Generation and analysis of schizophrenia susceptibility candidate gene Grm3 KO mice.2009

    • Author(s)
      Nii T, Iwaki A, Sasaki T, Shibata A, Fukuyoshi Y, Sagata N, Nomura M, Fukumaki Y
    • Organizer
      The 32nd Annual Meeting of the Molecular Biology Society of Japan
    • Year and Date
      2009-12-12
  • [Presentation] Adult-onset spastic paraplegia type 2 with a novel mutation in exon 7 of PLP1An autopsy case2009

    • Author(s)
      Iwaki A, Suzuki SO, Arakawa K, Furuya H, Fujii N, Fukumaki Y, and Iwaki T.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Year and Date
      2009-10-21

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Published: 2013-07-31  

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