2011 Fiscal Year Final Research Report
The role of epigenetic regulation of gene expression in progression of undifferentiated-type gastric carcinomas
| Project/Area Number |
21590369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MUKAISHO Ken-ichi 滋賀医科大学, 医学部, 准教授 (50343223)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 未分化型胃癌 / epigenetics / がん進展 / アレイCGH / クラスター解析 / 上皮間葉転換 / インテグリン / 腸形質 |
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| Research Abstract |
We have demonstrated that gene expression pattern of cancer may eventually become genomic dosage-dependent due to the attenuation of epigenetic regulation during tumor progression. If this is true, we can predict the progression risk of the cancer by the pattern of copy-number alterations of specified genes. In gastric cancer(GC), candidates of such genes were found to include many genes related to intestinal expression and epithelial mesenchymal transition in differentiated-type GC and integrin genes in undifferentiated-type GC in addition to MYC and TP53.
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