Biological significance of bone marrow-derived mesenchymal stem cells in tumor microenvironment

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kobe University
• Principal Investigator: SEMBA Shuho 神戸大学, 大学院・医学研究科, 准教授 (00302092)
• Project Period (FY): 2009 – 2011
• Keywords: がん幹細胞 / 骨髄由来間葉系幹細胞 / がん微小環境

Research Abstract

Bone marrow-derived mesenchymal stem cells-mediated activations of the WNT and TGF-βsignaling pathways were thought to provide advantageous microenvironments for cancer progression by supporting the re-acquisition and maintenance of cancer stem cells.

Research Products

• [Journal Article] 胃癌細胞と線維芽細胞・間葉系幹細胞の相互作用 (2012)
  • Author(s): 仙波秀峰
  • Journal Title: 胃がんperspective Volume: 5巻 Pages: 14-23
• [Journal Article] Bio logical significance of tumor budd ing at the invasive front of human colo rectal carcinoma cells (2012)
  • Author(s): Ysura, Semba S, Yokozaki H
  • Journal Title: Int J Oncol Volume: 41 Pages: 201-210
  • Peer Reviewed
• [Journal Article] 骨髄由来間葉系幹細胞によるがん幹細胞性再獲得機構 (2011)
  • Author(s): 仙波秀峰
  • Journal Title: 顕微鏡 Volume: 46巻 Pages: 89-94
• [Journal Article] Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxiainducible factor-1α-dependent manner in pancreatic cancer cells (2011)
  • Author(s): Semba S, Chiba S, Ku Y, Yokozaki H, Hori Y
  • Journal Title: Pathobiology Volume: 78 Pages: 181-192
  • Peer Reviewed
• [Journal Article] Regulation of PTEN expression by the SWI/SNF chromatin-remodelling pro tein BRG1 in human colorectal carcin oma cells (2011)
  • Author(s): Watanabe T, Semba S, Yokozaki H
  • Journal Title: Br J Cancer Volume: 104 Pages: 146-154
  • Peer Reviewed
• [Journal Article] Requirement of phosphatase of re generating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma (2010)
  • Author(s): Semba S, Mizuuchi E, Yokozaki H
  • Journal Title: Cancer Sci Volume: 101 Pages: 2254-2261
  • Peer Reviewed
• [Journal Article] Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma : clinical and histopathologic correla tions (2010)
  • Author(s): Maeda N, Semba S, Nakayama S, Yanagihara K, Yokozaki H
  • Journal Title: Virchows Arch Volume: 457 Pages: 423-432
  • Peer Reviewed
• [Journal Article] Constitu tive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo (2010)
  • Author(s): Matsukawa Y, Semba S, Kato H, Koma Y, Yanagihara K, Yokozaki H
  • Journal Title: Pathobiology Volume: 77 Pages: 155-162
  • Peer Reviewed
• [Journal Article] Negative regulation of the tight junction protein tricellulin by snail-induced epithelialmesenchymal transition in gastric carcinoma cells (2010)
  • Author(s): Masuda R, Semba S, Mizuuchi E, Yanagihara K, Yokozaki H
  • Journal Title: Pathobiology Volume: 77 Pages: 106-113
• [Journal Article] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells (2009)
  • Author(s): Semba S, Kodama Y, Ohnuma K, Mizuuchi E, Masuda R, Yashiro M, Hirakawa K, Yokozaki H
  • Journal Title: Br J Cancer Volume: 101 Pages: 1365-1373