Significance of Annexin A5 in atherothrombosis

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: SATO Yuichiro 宮崎大学, 医学部, 助教 (90347055)
• Co-Investigator(Kenkyū-buntansha): MARUTSUKA Kosuke 宮崎大学, 医学部, 准教授 (00239154) ; HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735) ; YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
• Project Period (FY): 2009 – 2011
• Keywords: 人体病理 / 血栓 / 動脈硬化 / Annexin A5

Research Abstract

We studied the immunohistochemical study or PCR study of annexin A5 in thrombosis. No apparent annexin A5 was detected in thrombi by immunohistochemical study or PCR study. Next, we examined the annexin A5 by flow chamber study and rabbit thrombosis model. No annexin A5 was detected in these models. Annexin A5 was not associated with thrombosis.

Research Products

• [Journal Article] Characteristics of tumor vessels in squash smears of astrocytic tumors (2011)
  • Author(s): Sato S, Sato Y, Marutsuka K, Takeshima K, Asada Y
  • Journal Title: Cytopathology Volume: 30 Pages: 16-21
  • Peer Reviewed
• [Journal Article] Quantitative analysis of vessels with smooth muscle layer in astrocytic tumors : correlation with histological grade and prognostic significance (2011)
  • Author(s): Sato S, Sato Y, Hatakeyama K, Marutsuka K, Yamashita A, Takeshima H, Asada Y
  • Journal Title: Hist Histopathol Volume: 26 Pages: 497-504
  • Peer Reviewed
• [Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. (2011)
  • Author(s): Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, Moriguchi-Goto S, Hatakeyama K, Takahashi M, Koshimoto C, Matsuura Y, Iwakiri T, Chen YE, Fan J, Asada Y
  • Journal Title: J Thromb Haemost Volume: 9 Pages: 201-208
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis (2010)
  • Author(s): Takahashi M, Yamashita A, Moriguchi-Goto S, Sugita C, Matsumoto T, Matsuda S, Sato Y, Kitazawa T, Hattori K, Shima M, Asada Y
  • Journal Title: Thromb Res Volume: 125 Pages: 464-70
  • Peer Reviewed
• [Journal Article] Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients (2010)
  • Author(s): Yano Y, Matsuda S, Hatakeyama K, Sato Y, Imamura T, Shimada K, Kodama T, Kario K, Asada Y
  • Journal Title: J Gerontol A Biol Sci Med Sci Volume: 65-5 Pages: 547-52
  • Peer Reviewed
• [Journal Article] Pericardial fat inflammation correlates with coronary artery disease (2010)
  • Author(s): Konishi M, Sugiyama S, Sato Y, Oshima S, Sugamura K, Nozaki T, Ohba K, Matsubara J, Sumida H, Nagayoshi Y, Sakamoto K, Utsunomiya D, Awai K, Jinnouchi H, Matsuzawa Y, Yamashita Y, Asada Y, Kimura K, Umemura S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 213-2 Pages: 649-55
  • Peer Reviewed
• [Presentation] 新しい診断基準を用いた絨毛膜羊膜炎の組織学的検討 (2011)
  • Author(s): 佐藤勇一郎、浅田祐士郎、丸塚浩助、山田直史、鮫島浩、池ノ上克
  • Organizer: 第19回日本胎盤学会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 20110930-1001
• [Presentation] Proportion of platelets, fibrin, and red blood cells differs in cardioembolic and atherothrombotic thrombi (2011)
  • Author(s): Sato Y, Ueda H, Hatakeyama K, Yamashita A, Asada Y
  • Organizer: XXIII Congress of International Society on Thrombosis and Haematosis
  • Place of Presentation: Kyoto
  • Year and Date: 20110723-28
• [Presentation] 乏突起膠細胞系腫瘍診断における術中細胞診の有用性 (2010)
  • Author(s): 佐藤信也、徳満貴子、佐藤勇一郎、神田修司、大野昭信、丸塚浩助
  • Organizer: 第49回日本臨床細胞学会秋期大会
  • Place of Presentation: 神戸
  • Year and Date: 20101121-22
• [Presentation] Decreased expression of CD39 in symptomatic carotid artery plaques (2010)
  • Author(s): Sato Y, Moriguchi-Goto S, Hatakeyama K, Marutsuka K, Asada Y
  • Organizer: The 6th congress of Asia Pacific Society on Thrombosis and Haemostasis
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 20101013-16
• [Presentation] 圧挫標本による脳腫瘍血管の形態学的検討 (2010)
  • Author(s): 佐藤信也、佐藤勇一郎、丸塚浩助、浅田祐士郎
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100427-29
• [Presentation] 臍帯動脈血栓症の一例 (2010)
  • Author(s): 佐藤勇一郎、山田直志、木許恭宏、中原彰彦
  • Organizer: 第30回日本小児病理研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-04
• [Presentation] 右心室血栓症、冠動脈血栓症を伴った特発性好酸球増多症候群の1剖検例 (2009)
  • Author(s): 佐藤勇一郎、畠山金太、丸塚浩介、浅田祐士郎
  • Organizer: 第31回心筋生検研究会
  • Place of Presentation: 大阪吹田市
  • Year and Date: 20091127-28
• [Book] 臍帯異常-胎児死亡と胎盤病理、産科と婦人科 (2011)
  • Author(s): 佐藤勇一郎
  • Total Pages: 727-732
• [Book] 冠動脈プラークの病理-虚血性心疾患の基礎知識 (2010)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Total Pages: 1535-1537
  • Publisher: 医学書院
• [Book] 病理学的見地からみた石灰化 (2009)
  • Author(s): 佐藤勇一郎、浅田祐士郎
  • Total Pages: 62-64
  • Publisher: 産業開発機構
• [Remarks]
  • URL: http://www.miyazaki-med.ac.jp/patho1/index.htm