Role of expression of HAI-1 and LRP11 in Lung Cnacer

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: TANAKA Hiroyuki 宮崎大学, 医学部, 助教 (90433060)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Hiroaki 宮崎大学, 医学部, 教授 (10214321)
• Project Period (FY): 2009 – 2011
• Keywords: 肺癌 / HGF : Hepatocyte growth factor / HGF activator inhibitor type-1 / LRP11 : Low density lipoprotein receptor-related protein 11

Research Abstract

1. We found that HAI-1 is expressed by the bronchial respiratory epithelium with basolateral localization.
2. In the injured pulmonary tissue, HAI-1 showed distinct apical translocation in ciliated epithelial cells of the bronchiole.
3. Distinct expression of LRP mRNA was observed in the brain, prostate, testis and lung tissue.
4. Expression of LRP11 mRNA was increased in non-small cell lung cancer as compared with normal lung tissue.
5. In pulmonary adenocarcinoma group, the correlation of clinicopathologic stage and expression ofLRP11 mRNA was suggested.
6. In pulmonary squamous cell carcinoma group, expression of LRP11 mRNA appears to be increased as compared with normal lung tissue.

Research Products

• [Journal Article] Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-{kappa} B, on glioblastoma (2012)
  • Author(s): Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
  • Journal Title: Neuro Oncol.
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor activator inhibitor type 1 suppresses metastaticpulmonary colonization of pancreatic carcinoma cells (2011)
  • Author(s): Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H
  • Journal Title: Cancer Sci Volume: 102-2 Pages: 407-13
  • Peer Reviewed
• [Journal Article] Improvement ofrheumatoid arthritis and autoimmune hepatitis in a patient treated with the tumor necrosis factor inhibitor, etanercept (2011)
  • Author(s): Umekita K, Miyauchi S, Ueno S, Takajo I, Kusumoto K, Hasuike S, Umekita Y, Tanaka H, Nagata K, Nagatomo Y, Kataoka H, Shimoda K, Okayama A
  • Journal Title: Intern Med Volume: 50-11 Pages: 1245-9
  • Peer Reviewed
• [Journal Article] Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth (2010)
  • Author(s): Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H
  • Journal Title: Int J Cancer Volume: 126-7 Pages: 1611-20
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases (2009)
  • Author(s): Cheng H, Fukushima T, Takahashi N, Tanaka H, Kataoka H
  • Journal Title: Cancer Res Volume: 69-5 Pages: 1828-35
  • Peer Reviewed
• [Journal Article] Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells (2009)
  • Author(s): Tanaka H, Fukushima T, Yorita K, Kawaguchi M, Kataoka H
  • Journal Title: Hum Cell Volume: 22-1 Pages: 11-7
  • Peer Reviewed
• [Presentation] 多彩な組織像を示した卵巣明細胞腺癌の一剖検例 (2010)
  • Author(s): 田中弘之
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] アントラサイクリン関連心筋炎と考えられた一剖検例 (2009)
  • Author(s): 田中弘之
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-02
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/patho2/index.html