Significance of microRNA in T-cell malignancies

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590377
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: INAGAKI Hiroshi 名古屋市立大学, 大学院・医学研究科, 教授 (30232507)
• Project Period (FY): 2009 – 2011
• Keywords: 成人T細胞性白血病 / マイクロRNA / 臨床病理学 / 遺伝子異常 / T細胞 / 機能解析

Research Abstract

Using microRNA array and quantitative PCR for some cell lines, we screened six microRNAs that may be important in adult T-cell leukemia/lymphoma(ATLL). Clinicopathological analysis of these six microRNAs showed that overexpression of one of these microRNAs(microRNA-X) was significantly associated with worse prognosis of the ATLL patients. Downregulation of microRNA-X by siRNA was associated with suppressed growth of the tumor cells of an ATLL cell line. These findings suggest that microRNA-X may play an important role in ATLL.

Research Products

• [Journal Article] Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis : a study of the Osaka Lymphoma Study Group (2012)
  • Author(s): Wada N, Zaki MA, Kohara M, Ogawa H, Sugiyama H, Nomura S, Matsumura I, Hino M, Kanakura Y, Inagaki H, Morii E, Aozasa K
  • Journal Title: Histopathology Volume: (in press)
• [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma (2012)
  • Author(s): Nishikawa H, Maeda Y, Ishida T, Gnjatic S, Sato E, Mori F, Sugiyama D, Ito A, Fukumori Y, Utsunomiya A, Inagaki H, Old LJ, Ueda R, Sakaguchi S
  • Journal Title: Blood Volume: 119 Pages: 3097-104
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody(KW-0761) for relapsed adult T-cell leukemia-lymphoma : A multicenter phase II study (2012)
  • Author(s): Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, Saburi Y, Miyamoto T, Takemoto S, Suzushima H, Tsukasaki K, Nosaka K, Fujiwara H, Ishitsuka K, Inagaki H, Ogura M, Akinaga S, Tomonaga M, Tobinai K, Ueda R
  • Journal Title: J Clin Oncol Volume: 30 Pages: 837-42
• [Journal Article] Characterization of chromosomal aberrations in thymic MALT lymphoma (2012)
  • Author(s): Kominato S, Nakayama T, Sato F, Yamada S, Xia H, Fujiyoshi Y, Hattori H, Inagaki H
  • Journal Title: Pathol Int Volume: 62 Pages: 93-8
• [Journal Article] The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma (2011)
  • Author(s): Ebi M, Kataoka H, Shimura T, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Tsukamoto H, Ozeki K, Tanida S, Kamiya T, Inagaki H, Joh T
  • Journal Title: Mol Med Report Volume: 4 Pages: 1151-51
• [Journal Article] Light-chain-restricted monocytoid B-cell cluster in reactive lymphadenitis associated with Sjogren syndrome (2011)
  • Author(s): Kojima M, Nakamura N, Nakazato Y, Igarashi T, Masawa N, Inagaki H
  • Journal Title: Leuk Lymphoma Volume: 52 Pages: 1150-2
• [Journal Article] Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma (2011)
  • Author(s): Xia H, Nakayama T, Sakuma H, Yamada S, Sato F, Takino H, Okabe M, Fujiyoshi Y, Hattori H, Inagaki H
  • Journal Title: Hum Pathol Volume: 42 Pages: 1297-304
• [Journal Article] Analysis of VH gene rearrangement and somatic hypermutation in Sjogren's syndrome and IgG4-related sclerosing sialadenitis (2010)
  • Author(s): Sakuma H, Okumura F, Miyabe S, Sugiura M, Joh T, Shimozato K, Inagaki H
  • Journal Title: Scand J Immunol Volume: 72 Pages: 44-9
• [Journal Article] A complement-dependent, cytotoxicityenhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model (2010)
  • Author(s): Sato F, Ito A, Ishida T, Mori F, Takino H, Inagaki A, Ri M, Kusumoto S, Komatsu H, Iida S, Okada N, Inagaki H, Ueda R
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 1791-800
• [Journal Article] Presence of immunoglobulin heavy chain rearrangement in so-called "plasma cell granuloma of the lung" (2010)
  • Author(s): Kojima M, Nakamura N, Itoh H, Kamiyoshihara M, Matsumoto M, Nakazato N, Fujisawa T, Motoori T, Masawa N, Inagaki H
  • Journal Title: Pathol Res Pract Volume: 206 Pages: 83-7
• [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma (2010)
  • Author(s): Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
  • Journal Title: J Clin Oncol Volume: 28 Pages: 1591-8
• [Journal Article] Cyclin D1 protein overexpression in extramedullary plasmacytoma : A clinicopathologic study of 11 cases (2009)
  • Author(s): Kojima M, Motoori T, Tamaki Y, Igarashi T, Matsumoto M, Shimizu K, Ogawa A, Itoh H, Asano S, Masawa N, Inagaki H
  • Journal Title: J Clin Exp Hemato Volume: 49 Pages: 53-6
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model (2009)
  • Author(s): Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
  • Journal Title: Cancer Immunol Immunother Volume: 58 Pages: 1195-206
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo (2009)
  • Author(s): Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
  • Journal Title: J Immunol Volume: 183 Pages: 4782-91
• [Journal Article] B-cell lymphoma associated with Sjogren's syndrome among Japanese patients : a clinicopathologic and immunohistochemical study of 15 cases (2009)
  • Author(s): Kojima M, Tsukamoto N, Yokohama A, Suzuki Y, Shimizu K, Nishikawa M, Murayama K, Miyanaga T, Isoda A, Shimizu K, Itoh H, Masawa N, Yoshida K, Inagaki H
  • Journal Title: J Clin Exp Hemato Volume: 49 Pages: 89-95
• [Journal Article] Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model
  • Author(s): Mori F, Ishida T, Ito A, Sato F, Masaki A, Takino H, Ri M, Kusumoto S, Komatsu H, Ueda R, Inagaki H, Iida S
  • Journal Title: Blood Cancer Journal Volume: (In press)
• [Journal Article] FOXP1 overexpression and its clinicopathological significance in peripheral T-cell lymphoma, not otherwise specified
  • Author(s): Yamada S, Sato F, Xia H, Takino H, Kominato S, Ri M, Ishida T, Iida S, Inagaki H, Yamada K
  • Journal Title: Hum Pathol Volume: (in press)
• [Journal Article] Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis
  • Author(s): Okumura F, Sakuma H, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Yoshida M, Yamashita H, Ohara H, Inagaki H, Joh T
  • Journal Title: Pathol Int Volume: (in press)
• [Presentation] Bevacizumab-induced potent antiyumor effect in a microenvironment-dependent mouse lymphoma model (2011)
  • Author(s): Mori F, Inagaki H, et al
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 20111014-16
• [Presentation] Late relapse more than 5 years following limited-stage extranodal NK/T cell lymphoma, nasal type (2011)
  • Author(s): Totani H, Inagaki H, et al
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 20111014-16
• [Presentation] Establishment of an angioimmunoblastic T-cell lymphoma(AITL) model in the NOG mounse (2011)
  • Author(s): Ito A, Inagaki H, et al
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 20111014-16
• [Presentation] Potent Tax-specific CTL response to primay autologous ATL cells (2011)
  • Author(s): Suzuki S, Inagaki H, et al
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 20111014-16
• [Presentation] Differential effect of thalidomide in the treatment of POEMS syndrome : Two case reports (2011)
  • Author(s): Yoshida T, Inagaki H, et al
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 20111014-16
• [Presentation] 自己免疫性膵炎の免疫グロブリン遺伝子解析 (2011)
  • Author(s): 佐久間英規、稲垣宏、他
  • Organizer: 第51回日本リンパ網内系学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 20110630-0702
• [Presentation] NOGマウスによるT細胞性リンパ腫の病態解明 (2011)
  • Author(s): 伊藤旭, 稲垣宏, 他
  • Organizer: 第51回日本リンパ網内系学会シンポジウム(招待講演)
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 20110630-0702
• [Presentation] シェーグレン症候群およびIgG4関連慢性硬化性唾液腺炎における免疫グログリン重鎖遺伝子解析 (2011)
  • Author(s): 佐久間英規、稲垣宏、他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20110426-28
• [Presentation] 非特定末梢型T細胞リンパ腫におけるFOXP1遺伝子発現の臨床病理学的意義 (2011)
  • Author(s): 山田勢至、稲垣宏、他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20110426-28
• [Presentation] NOGマウスリンパ腫モデルに対してCDC増強抗CD20抗体の抗腫瘍活性の検討 (2011)
  • Author(s): 佐藤文彦、稲垣宏、他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20110426-28
• [Presentation] 成人T細胞白血病・リンパ腫におけるマイクロRNA発現異常の解析 (2011)
  • Author(s): 夏洪晶、稲垣宏、他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20110426-28
• [Presentation] A CDC-enhancing anti-CD20 mAb mediating potent antitumor activity in the humanized NOG mouse model (2010)
  • Author(s): Ito A, Inagaki H, et al
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20100924-26
• [Presentation] 肺MALTリンパ腫における遺伝子異常とIgH遺伝子体細胞変異 (2010)
  • Author(s): 夏洪晶, 稲垣宏, 他
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 20100618-19
• [Presentation] 縦隔・胸腺のリンパ増殖性疾患の診断シンポジウム2縦隔腫瘍の多様性はどこまでわかってきたか (2010)
  • Author(s): 稲垣宏
  • Organizer: 第99回日本病理学会総会(招待講演)
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 20100427-29
• [Presentation] 造血系腫瘍の病理学的概要 (2009)
  • Author(s): 稲垣宏
  • Organizer: 第3回伴侶動物の臨床医学研究会(招待講演)
  • Place of Presentation: 岡崎コンファレンスセンター(愛知)
  • Year and Date: 20091203-05
• [Presentation] 悪性リンパ腫:病理診断と治療 (2009)
  • Author(s): 稲垣宏
  • Organizer: 第48回中部医学検査学会(招待講演)
  • Place of Presentation: 三島市民文化会館(静岡)
  • Year and Date: 20091107-08
• [Presentation] ヒト免疫担当細胞移入NOD/Shi-scid, IL2Rgamma null(NOG)マウスを用いた抗体療法評価システムの確立 (2009)
  • Author(s): 伊藤旭、稲垣宏、他
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 20091023-25
• [Presentation] EBER陽性のALK陰性anaplastic large cell lymphoma(ALCL)の2例 (2009)
  • Author(s): 稲垣淳、稲垣宏、他
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 20091023-25
• [Presentation] B-LBLモデルマウスの樹立及び病態解析 (2009)
  • Author(s): 森芙美子、稲垣宏、他
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 20091023-25
• [Presentation] ヒト免疫担当細胞移入NOD/Shi-scid, IL2Rgamma null(NOG)マウスを用いた抗体療法評価システムの確立 (2009)
  • Author(s): 伊藤旭、稲垣宏、他
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20091001-03
• [Presentation] 胸腺MALTリンパ腫における遺伝子過剰メチル化とFas遺伝子異常の解析 (2009)
  • Author(s): 滝野寿、稲垣宏、他
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 20090501-03
• [Book] 癌診療指針のための病理診断プラクティス:食道癌・胃癌 (2012)
  • Author(s): 稲垣宏, 楠本茂, 片岡洋望
  • Total Pages: 307
  • Publisher: 中山書店
• [Book] 癌診療指針のための病理診断プラクティス:リンパ球増殖疾患 (2010)
  • Author(s): 稲垣宏, 楠本茂
  • Total Pages: 335
  • Publisher: 中山書店
• [Book] WHO血液腫瘍分類WHO分類2008をうまく活用するために (2010)
  • Author(s): 佐藤文彦、稲垣宏
  • Total Pages: 587
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/patho2.dir/4pep.html