2011 Fiscal Year Final Research Report
Significance of microRNA in T-cell malignancies
| Project/Area Number |
21590377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
INAGAKI Hiroshi 名古屋市立大学, 大学院・医学研究科, 教授 (30232507)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 成人T細胞性白血病 / マイクロRNA / 臨床病理学 / 遺伝子異常 / T細胞 / 機能解析 |
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| Research Abstract |
Using microRNA array and quantitative PCR for some cell lines, we screened six microRNAs that may be important in adult T-cell leukemia/lymphoma(ATLL). Clinicopathological analysis of these six microRNAs showed that overexpression of one of these microRNAs(microRNA-X) was significantly associated with worse prognosis of the ATLL patients. Downregulation of microRNA-X by siRNA was associated with suppressed growth of the tumor cells of an ATLL cell line. These findings suggest that microRNA-X may play an important role in ATLL.
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Research Products
(43 results)
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[Journal Article] Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis : a study of the Osaka Lymphoma Study Group2012
Author(s)
Wada N, Zaki MA, Kohara M, Ogawa H, Sugiyama H, Nomura S, Matsumura I, Hino M, Kanakura Y, Inagaki H, Morii E, Aozasa K
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Journal Title
Histopathology
Volume: (in press)
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[Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma2012
Author(s)
Nishikawa H, Maeda Y, Ishida T, Gnjatic S, Sato E, Mori F, Sugiyama D, Ito A, Fukumori Y, Utsunomiya A, Inagaki H, Old LJ, Ueda R, Sakaguchi S
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Journal Title
Blood
Volume: 119
Pages: 3097-104
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[Journal Article] Defucosylated anti-CCR4 monoclonal antibody(KW-0761) for relapsed adult T-cell leukemia-lymphoma : A multicenter phase II study2012
Author(s)
Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, Saburi Y, Miyamoto T, Takemoto S, Suzushima H, Tsukasaki K, Nosaka K, Fujiwara H, Ishitsuka K, Inagaki H, Ogura M, Akinaga S, Tomonaga M, Tobinai K, Ueda R
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Journal Title
J Clin Oncol
Volume: 30
Pages: 837-42
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[Journal Article] The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma2011
Author(s)
Ebi M, Kataoka H, Shimura T, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Tsukamoto H, Ozeki K, Tanida S, Kamiya T, Inagaki H, Joh T
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Journal Title
Mol Med Report
Volume: 4
Pages: 1151-51
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[Journal Article] Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma2011
Author(s)
Xia H, Nakayama T, Sakuma H, Yamada S, Sato F, Takino H, Okabe M, Fujiyoshi Y, Hattori H, Inagaki H
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Journal Title
Hum Pathol
Volume: 42
Pages: 1297-304
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[Journal Article] A complement-dependent, cytotoxicityenhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model2010
Author(s)
Sato F, Ito A, Ishida T, Mori F, Takino H, Inagaki A, Ri M, Kusumoto S, Komatsu H, Iida S, Okada N, Inagaki H, Ueda R
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Journal Title
Cancer Immunol Immunother
Volume: 59
Pages: 1791-800
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[Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma2010
Author(s)
Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
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Journal Title
J Clin Oncol
Volume: 28
Pages: 1591-8
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[Journal Article] Cyclin D1 protein overexpression in extramedullary plasmacytoma : A clinicopathologic study of 11 cases2009
Author(s)
Kojima M, Motoori T, Tamaki Y, Igarashi T, Matsumoto M, Shimizu K, Ogawa A, Itoh H, Asano S, Masawa N, Inagaki H
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Journal Title
J Clin Exp Hemato
Volume: 49
Pages: 53-6
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[Journal Article] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model2009
Author(s)
Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
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Journal Title
Cancer Immunol Immunother
Volume: 58
Pages: 1195-206
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[Journal Article] Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo2009
Author(s)
Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
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Journal Title
J Immunol
Volume: 183
Pages: 4782-91
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[Journal Article] B-cell lymphoma associated with Sjogren's syndrome among Japanese patients : a clinicopathologic and immunohistochemical study of 15 cases2009
Author(s)
Kojima M, Tsukamoto N, Yokohama A, Suzuki Y, Shimizu K, Nishikawa M, Murayama K, Miyanaga T, Isoda A, Shimizu K, Itoh H, Masawa N, Yoshida K, Inagaki H
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Journal Title
J Clin Exp Hemato
Volume: 49
Pages: 89-95
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[Journal Article] Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model
Author(s)
Mori F, Ishida T, Ito A, Sato F, Masaki A, Takino H, Ri M, Kusumoto S, Komatsu H, Ueda R, Inagaki H, Iida S
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Journal Title
Blood Cancer Journal
Volume: (In press)
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[Journal Article] FOXP1 overexpression and its clinicopathological significance in peripheral T-cell lymphoma, not otherwise specified
Author(s)
Yamada S, Sato F, Xia H, Takino H, Kominato S, Ri M, Ishida T, Iida S, Inagaki H, Yamada K
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Journal Title
Hum Pathol
Volume: (in press)
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[Journal Article] Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis
Author(s)
Okumura F, Sakuma H, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Yoshida M, Yamashita H, Ohara H, Inagaki H, Joh T
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Journal Title
Pathol Int
Volume: (in press)
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