2011 Fiscal Year Final Research Report
Genetic alteration in the short telomere lesion as a precancerous lesion of gastric cancer
| Project/Area Number |
21590380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
FUJII Kiyomu 奈良県立医科大学, 医学部, 研究員 (60284189)
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
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| Co-Investigator(Renkei-kenkyūsha) |
OHMORI Hitoshi 奈良県立医科大学, 医学部, 研究員 (80213875)
SASAHIRA Tomonori 奈良県立医科大学, 医学部, 助教 (90405374)
UJJAL Bhawal 奈良県立医科大学, 医学部, 研究員 (50433339)
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| Project Period (FY) |
2009 – 2011
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| Keywords | テロメア / 胃癌 / 幹細胞因子 / ステムネス / 前癌病変 |
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| Research Abstract |
Telomere is shortened in gastric cancer. A semi-quantitative and geographic analysis of telomere in non-cancerous gastric mucosa showed the localized mucosal area with shortened telomere, which was named as short telomere lesion(STL)". In this project, specific genetic alterations in STL were examined. TDGF-2, which is one of pseudogene of CR-1, was deleted in high frequency in STL. TDGF-2 gene product inhibited the physical association of CR-1 and Nodal. The lack of TDGF-2 as a CR-1 negative regulator induced activation of CR-1-Nodal pathway, which might provoke stem cell hyperplasia in gastric epithelium. A variant type of CTP2D6 was expressed in STL, which might affect the metabolism of genotoxic substances.
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