2011 Fiscal Year Final Research Report
Application of dual-color CISH for pathological diagnosis and extraction of prognostic factors in bone and soft tissue sarcomas
| Project/Area Number |
21590386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University (2011)
Teikyo University (2009-2010) |
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Principal Investigator |
MOTOI Tooru 東京医科大学, 医学部, 兼任講師 (50291315)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Arisa 帝京大学, 医学部, 教務職員 (50596963)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAMURA Tetsuo 帝京大学, 医学部, 教授 (40010566)
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| Project Period (FY) |
2009 – 2011
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| Keywords | CISH法 / 肉腫 / 分子病理診断 / 染色体相互転座 / 融合遺伝子 / 遺伝子増幅 |
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| Research Abstract |
Accurate pathological diagnosis of sarcoma is indispensable for appropriate therapy. However, rarity and wide variety of histological types make tumor diagnosis difficult. In this study, a detection method which enables simultaneous visualization of morphology and cytogenetic abnormalities under a light microscope is established and verified. The new method is applicable for routine pathological diagnosis without using special equipment for molecular biology. Therefore diagnostic accuracy may be improved by the present method.
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Research Products
(27 results)
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[Journal Article] Inhibin-αand synaptophysin immunoreactivity in synovial sarcoma with granular cell features2012
Author(s)
Setsu N, Kohashi K, Endo M, Yamamoto H, Ohishi Y, Sueyoshi K, Iwamoto Y, Tsuneyoshi M, Motoi T, Kumagai A, Oda Y
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Journal Title
Hum Pathol
Volume: 43(6)
Pages: 850-7
DOI
Peer Reviewed
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