2011 Fiscal Year Final Research Report
A clonality analysis of breast cancer tissue with heterogenity : clarifying the cell lineage for adequate treatment strategy for recurrent tumor
| Project/Area Number |
21590387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nihon University (2010-2011)
Tokai University (2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OSAMURA Yoshiyuki 東海大学, 医学部, 教授 (10100992)
TOKUDA Yutaka 東海大学, 医学部, 教授 (20163975)
TAKEKOSHI Susumu 東海大学, 医学部, 准教授 (70216878)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 乳癌 / 遺伝子変異多様性 / クロナリティー / ミトコンドリアDNA D-loop領域 |
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| Research Abstract |
Aim : To clarify the cell lineage of breast cancer cells the present study was performed. It is significant to understand which cancer cells were recurrent from the initial breast cancer tissue with heterogeneity. The final goal of this study is to provide information for the adequate treatment of recurrent breast cancer.
Materials and methods : Formalin-fixed paraffin-embedded sections of the lymph node, the surrounding mammary gland and breast cancer tissue from the patients who had second breast tumors in ipsilateral and contralateral mammary gland after the treatment for initial breast cancer. Two analysis methods, polymorphism of human androgen receptor(HUMARA) and gene alteration of mitochondrial D-loop somatic mutation(GAMDDL) were compared.
Results and conclusion : The informative rate of analyses was 42.1%, 76.9% and 89.5% by HUMARA, GAMDDL, and combined HUMARA and GAMDDL, respectively. GAMDDL is a useful method to clarify the cell lineage of cancer cells.
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Research Products
(16 results)
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[Journal Article] Recommendation for "Adequate evaluation of hotmonr receptor": A report of task force of Japanese Breast Cancer Society2010
Author(s)
Umemura S, Kurosumi M, Moriya T, Oyama T, Arihiro K, Yamashita H, Umekita Y, Komoike Y, Shimizu C, Fukushima H, Kajiwara H, Akiyama F
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Journal Title
Oncology Reports
Volume: 24
Pages: 299-304
Peer Reviewed
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[Journal Article] Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastinc receptor2009
Author(s)
Shoji S, Tang XY, Umemura S, Itoh J, Takekoshi S, Shima M, Usui Y, Nagata Y, Uchida T, Osamura RY, Terachi T
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Journal Title
Eur Urology
Volume: 55
Pages: 441-451
Peer Reviewed
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