2011 Fiscal Year Final Research Report
Clinicopathological significance and epigenetic alterations of miRNAs in gastric cancer
| Project/Area Number |
21590396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AKIYAMA Yoshimitsu 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (80262187)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子病理 / エピジェネティクス |
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| Research Abstract |
The mechanism underlying the aberrant miRNA expression in gastric carcinogenesis remains unclear. Here we observed that miR-181c and miR-212 were epigenetically regulated in gastric cancers(GCs). Methylation status at the CpG island of miR-181c was strongly related to its expression levels. Over-expression of these miRNAs significantly reduced cell proliferation, suggesting a tumor suppressive function. Moreover, miR-9 expression was high in GCs with lymph node metastasis and inversely associated with CDX2 expression. Thus altered expression of these miRNAs may contribute to gastric carcinogenesis.
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[Journal Article] Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas2010
Author(s)
Wen XZ, Akiyama Y, Pan KF, Liu ZJ, LuZM, Zhou J, Gu LK, Dong CX, Zhu BD, Ji JF, You WC, Deng DJ
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Journal Title
World Journal of Gastro-enterology
Volume: 16
Pages: 1201-1208
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[Journal Article] GATA4 and GATA5are potential tumor suppressors andbiomarkers in colorectal cancer2009
Author(s)
Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker C, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, CarvalhoB, Meijer GA, Baylin SB, Herman JG, deBru ne AP, van Engeland M
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Journal Title
Clinical Cancer Research
Volume: 15
Pages: 3990-3997
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