2011 Fiscal Year Final Research Report

Genome-wide microRNA expression profiling in gastric cancer

Research Project

Project/Area Number	21590398
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Human pathology
Research Institution	Oita University
Principal Investigator	MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
Co-Investigator(Kenkyū-buntansha)	TSUKAMOTO Yoshiyuki 大分大学, 医学部, 助教 (00433053)
Project Period (FY)	2009 – 2011
Keywords	マイクロアレイ / 網羅的解析
Research Abstract	We investigated expression profiles of microRNA(miRNA) in gastric carcinomas by use of a miRNA microarray platform covering a total of 470 human miRNAs. By comparing miRNA expression profiles between intestinal-type and diffuse-type gastric carcinomas(ANOVA P<0. 05), we could not identify any miRNAs differentially expressed between them, suggesting that, in gastric carcinomas, the miRNA expression profile might not be correlated with histopathologic subtypes. We identified 39 differentially expressed miRNAs in gastric carcinoma, of which 6 were significantly downregulated and the other 33 were upregulated. Among the 6 down-regulated miRNA, we selected 3, miR-375, miR-29c and miR-148a, as gastric cancer-related miRNA.

(5 results)