2011 Fiscal Year Final Research Report
Studies on the mechanisms of gut immune tolerance towards the suppression of allergic bowel diseases
| Project/Area Number |
21590409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
TORII Ikuko 兵庫医科大学, 医学部, 准教授 (70207661)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Tohru 兵庫医科大学, 医学部, 教授 (20227408)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子病 |
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| Research Abstract |
Gut has a tendency to show the immune tolerance towards the food antigen and the microbial flora. On the other hand, gut shows the active immune responses to prevent the attack of the pathogenic microbe and the harmful antigen. Imbalance of these immune reactions leads to the serious gut disorders like the inflammatory bowel diseases and food allergy. To elucidate the mechanisms of the maintenance of gut immune homeostasis, we generated a murine model showing the immune tolerance for the orally administered ovalbumin. By using this model, we obtained a result that some populations in the spleen are critical for the regulation of gut immune system.
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